Observational studies and clinical trials performed in general populations indicate that a higher salt intake is associated with development of hypertension, or aggravates hypertension that is already ...

Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension. We ...

Lorundrostat, a drug that blocks aldosterone production from the adrenal glands, showed significant and lasting reductions in blood pressure in 1,083 patients with uncontrolled or resistant ...

Hypertension affects 1 in 3 adults globally and is the leading modifiable risk factor for cardiovascular disease. Aldosterone dysregulation, often driven by obesity and primary aldosteronism, affects ...

Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase is ...

One of the functions of your adrenal glands is to produce a hormone called aldosterone that plays an active role in your blood pressure. It does this by maintaining the balance of sodium, potassium, ...

A team of medical researchers and doctors affiliated with multiple institutions in the U.S. has found, via clinical trial, that the aldosterone synthase inhibitor lorundrostat is likely safe to use ...

Mitochondrial dysfunction and redox imbalance are central drivers of cardiovascular disease, contributing to impaired bioenergetics, oxidative stress, ...

Exercise cannot reduce a sodium-retaining hormone, aldosterone, which is known to potentially cause hypertension in African Americans. Many African Americans develop the salt-sensitive form of ...

Hypertension affects one in three adults globally and is the leading modifiable risk factor for cardiovascular disease. Aldosterone dysregulation, often driven by obesity and primary aldosteronism, ...