Amides are among the most ubiquitous functional groups in organic chemistry, forming the backbone of peptides and playing a vital role in pharmaceutical, synthetic and materials chemistry. Their ...

Extending or trimming the length of a drug molecule’s carbon backbone by just a couple of atoms can significantly alter its activity, even if nothing else in the structure changes. So reactions that ...

Historically, one of the primary ways organic chemists have explored and created compounds is by constructing a carbon skeleton and making modifications to its structure. But instead of building a ...