Researchers have identified a mechanism by which acetylcholine, a neurotransmitter best known for its role in muscle control and attention, can effectively commandeer serotonin release inside the ...

About one-third of depression patients do not respond to standard antidepressants. A new treatment called PACE uses ...

Scientists have uncovered a brain mechanism that may explain why chronic pain leads to depression in some people but not ...

Researchers identify the hippocampus and microglia as the "tipping point" that determines if chronic pain leads to depression or resilience.

PHILADELPHIA— Researchers at Penn Medicine have identified specific brain circuits that are impacted by psilocybin—the active compound found in some psychedelic mushrooms—which could lead to new paths ...

Chronic pain affects more than 1.5 billion people worldwide and is often deeply entangled with depression and anxiety, creating a vicious cycle that amplifies suffering and impairs quality of life. A ...

A mouse model displaying depression-like behaviors was established by exposing animals to chronic variable stress (left). A multi-omics approach was then applied, using high-resolution mass ...

Changes to one's hippocampus, the brain's memory centre, in response to prolonged pain could be an important factor for why ...

Researchers at Penn Medicine have identified specific brain circuits that are impacted by psilocybin-the active compound found in some psychedelic mushrooms-which could lead to new paths forward for ...

Depression is a debilitating mental health disorder that remains a substantial global health challenge. Despite the availability of various antidepressants, treatment outcomes often face limited ...