The multisubunit condensin complex is essential for the structural organization of eukaryotic chromosomes during their segregation by the mitotic spindle, but the mechanistic basis for its function is ...

Scientists have identified how a specific variant of a key protein complex found in human cells called condensin can reorganize a cell's genetic architecture in such a way as to promote senescence, ...

Although distinct in structure and function, cohesin and condensin both contain conserved chromosomal ATPases of the structural maintenance of chromosomes (SMC) protein family. Present models indicate ...

Advances in our understanding of basic biological processes and human disease owe much to the groundbreaking research of scientists at the Chromosome Dynamics Laboratory at RIKEN Advanced Science ...

Remarkably, living cells are able to package a jumble of DNA over two meters in length into tidy, tiny chromosomes while preparing for cell division. However, scientists have been puzzled for decades ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

Frog egg extracts have yielded insights into the intricacies of what happens to chromosomes when our cells divide Experiments using extracts from African clawed frog eggs have revealed how a key ...

The first theoretical model of condensin, a molecular machine involved in packing and unpacking chromosomes, accurately reproduces all known experiments with just two parameters. To scrunch a ...

Stress can make you wish life had a pause button. Single-celled organisms like yeast actually have this option. Faced with a lack of food or other stressors, baker’s yeast can enter a “paused,” energy ...

A living cell is able to neatly package a big jumble of DNA into chromosomes while preparing for cell division. For over a century, scientists have been puzzled for decades on how the process works.

It's so impressive: a living cell is able to neatly package a big jumble of DNA, over two meters in length, into tidy, tiny chromosomes while preparing for cell division. For over a century, it has ...