Nature

DNA read count calibration for single-molecule, long-read sequencing

Long-read sequencers have been a boon for genomic studies by allowing long-distance sequence connections to be obtained directly and by providing single-molecule resolution of DNA and RNA species 1,2.
Nature

Circulating DNA and frequency of colorectal cancer brain metastases in a presumed high-risk group

This explorative prospective observational pilot study investigated if suggested risk factors, rectal cancer and lung metastases, could add to a relevant detection rate of asymptomatic brain ...
ascopubs.org

Leveraging high variant allele frequencies (VAF) of DNA damage repair (DDR) mutations (muts) in liquid biopsy (LBx) as a surrogate for germline testing: Implications for ...

Age-related germline landscape of endometrial cancer: Focus on early-onset cases. Estimated prevalence of pathogenic variants in patients with breast, colon, and/or endometrial cancer who do not meet ...
ascopubs.org

Association of circulating tumor DNA (ctDNA) variant allelic frequency (VAF) with outcomes on matched targeted therapies (TT) in advanced non-small cell lung cancer (aNSCLC).

Osimertinib plus anlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer with concurrent gene alterations: A single-arm, prospective, multicenter phase II study. Safety ...