Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Human disease including cancer arises from disfunction of essential processes within a cell. One essential cellular process is the copying of the genomic DNA—the road map of cells—followed by ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

The eukaryotic genome can be up to 130 billion base pairs long, but required to fit inside each cell nucleus. To do this, DNA is tightly wrapped around histone proteins in bead-like clusters. Each ...

Our group has contributed to the molecular and functional understanding of histone mark and DNA methylation mark readout by writer, reader and eraser proteins, as well as investigated the crosstalk ...

Nearly two years into the pandemic, we find ourselves thinking about viruses daily. Amid the dread of hearing about yet another new SARS-CoV-2 variant and longing for normalcy, perhaps you’ve ...

In a recent study published in the journal Science Advances, a group of researchers investigated the role of histone modifications in human aging by developing and evaluating histone-specific age ...