In vitro studies of polymorphonuclear-leukocyte function in two female patients with clinical and pathological features of chronic granulomatous disease of childhood showed defective bactericidal ...

The mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of immune cells that expose the antigens on their surface to activate the T cells, has ...

A new study identifies the defective function of CatSper, an ion channel controlling calcium levels in sperm, as a common cause of seemingly unexplained male infertility. CatSper-deficient human sperm ...

CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release–activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined ...

Intracellular accumulations of altered, misfolded proteins in neuronal and other cells are pathological hallmarks shared by many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS ...

Interim Phase 2 Data Showed a Combination of VX-770 and VX-809 Improved Function of the Defective Protein that Causes Cystic Fibrosis in People With the Most Common Form of the Disease -13.17 mmol/L ...

One of the most significant cells in the body is the macrophage. This immune cell, dubbed "big eater" in Greek, eats and breaks down dangerous substances like dust, debris, bacteria, and cancer cells.

PHILADELPHIA -- (Dec. 14, 2017) -- A new study from The Wistar Institute revealed the mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of ...

In half of the couples that are unable to conceive a child, the infertility is due to the man. A new study identifies the defective function of ‘CatSper’, an ion channel controlling calcium levels in ...

Dendritic cells (DC) are now recognized as essential regulators of both innate and acquired arms of the immune system. A new study from The Wistar Institute revealed the mechanism implicated in the ...