Researchers have created the first complete map showing how hundreds of mutations in a key cancer gene affect tumor growth.

Study results indicate that mutation strength may shape both tumor–immune system interactions and immunotherapy response.

MDR3 defects are involved in the development of PFIC3, LPAC, ICP, and DILI. Sterolin 1/2 are cotransporters that transport plant sterols and can lead to sitosterolemia if mutated. MRP2 is responsible ...