How major nuclear protein complexes control specialized gene regulation in cancer and beyond

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...
Nature

Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma

Lung cancer is the leading cause of cancer-associated deaths worldwide and has one of the poorest prognoses among all cancer types. Non-small cell lung carcinoma (NSCLC) comprises approximately 80% of ...
Nature

Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in ...

Fibroblast growth factor (FGF) signaling can bypass the requirement for estrogen receptor (ER) activation in the growth of ER-positive (ER+) breast cancer cells. Fibroblast growth factor-1 stimulation ...