Management of mitochondrial-related heart disease relies on multidisciplinary care and symptom control, as targeted gene-editing therapies are limited.

Mitochondrial DNA (mtDNA) editing has emerged as a revolutionary approach in the fight against neurodegenerative diseases (NDDs). As these diseases continue to impose a significant global health ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Researchers from Karolinska Institutet have discovered how mammalian cells prevent the gradual buildup of harmful mutations in mitochondrial DNA, the small but vital genome that powers every cell. The ...

One study reported 8 live births from 22 women with pathogenic mtDNA variants who underwent mitochondrial donation through pronuclear transfer. None had signs of mitochondrial disease and heteroplasmy ...