Understanding how genotypes are linked to phenotypes is important in biomedical and evolutionary studies. The chaperone heat-shock protein 90 (HSP90) buffers genetic variation by stabilizing proteins ...

We determined the structure and function of Heat Shock Protein 90 (Hsp90), a molecular chaperone which is critical for the growth and survival of cancer cells. We worked with partners to discover the ...

Direct binders to the N-terminal ATP/ADP pocket of Hsp90 inhibit Hsp90 ATPase activity. The ATP-regulatory pocket of Hsp90 is unique. While bound to Hsp90 the nucleotide adopts a bent shape found only ...

Integrative transcriptional analysis of enzalutamide-resistant castration resistant prostate cancer cells using RNA sequencing. Efficacy and safety of abiraterone acetate (AA) and low-dose prednisone ...

Tarveda Therapeutics agreed to discover, develop, and commercialize new cancer treatments based on Madrigal Pharmaceuticals’ HSP90 Drug Conjugate oncology platform—including its lead clinical ...

HSP90 chaperone undergoes dynamic cycling process: HSP90 transits between open and closed states to promote maturation of polypeptide clients into functional proteins with the help of ATP and a ...

A pair of recent papers show that inhibitors of the chaperone heat shock protein 90 (Hsp90) enhance the degradation of mutated or hyperphosphorylated tau protein in animal models of neurodegenerative ...

Cancer metastasis is the result of complex processes, including alteration of cell adhesion/motility in the microenvironment and neoangiogenesis, that are necessary to support cancer growth in tissues ...

Larger size extracellular vesicle as early biomarker in patients with metastatic pancreatic cancer. Effect of perioperative transfusion on recurrence and survival after resection of distal ...

If “Cold” Tumors Become “Hot,” They Respond Better to Checkpoint Blockade Immunotherapy The emergence and stunning early success of checkpoint blockade, a therapy that helps the immune system ...

HER2-positive breast cancer, known for its aggressive nature due to the overexpression of the HER2 protein, poses significant challenges in treatment. Current standard treatments for HER2-positive ...