Atherosclerosis underlies most heart attacks and strokes and is now recognized as a chronic inflammatory disease rather than ...

Using gene editing in a preclinical model, researchers at UT Southwestern Medical Center blocked the symptoms of a rare smooth muscle disease before they developed. Their findings, published in ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...

The same model also allows exploration of CICR in neurons, smooth muscle, and immune cells, expanding its clinical impact. With this insight, drug design can now focus on precision control of Ca²⁺ ...

In the fetal rat, nitrofen induces congenital diaphragmatic hernia (CDH) and pulmonary vascular remodeling similar to what is observed in the human condition. Airway hyperactivity is common in infants ...

Engineered BiTE molecule draws T cells to eliminate FAP+ modulated smooth muscle cells, reducing plaque burden across mouse atherosclerosis models.

Researchers have discovered that a key protein controls how stem cells 'choose' to become either skeletal muscle cells that move limbs, or smooth muscle cells that support blood vessels. The results ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...