Notch genes encode heterodimeric transmembrane receptors that regulate differentiation, proliferation and apoptosis 1,2. Mammals have four known Notch genes and two families of Notch ligands ...
ErbB-2 overexpression in breast tumors is associated with poor survival. Expression of Notch-1 and its ligand, Jagged-1, is associated with the poorest survival, including ErbB-2-positive tumors.
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