Reaction cascade of the complement system: classical, alternative, and lectin pathways, amplification loop, terminal pathway, and membrane attack complex.

The complement system’s elegance is also its complexity. Explore the interactions along the complement cascade in this interactive diagram to better understand the upstream and …

Complement can be activated via three different pathways (Figure 1), which can each cause the activation of C3, cleaving it into a large fragment, C3b, that acts as an opsonin, and a small …

Sep 14, 2025 · This illustration provides a detailed look at the complement cascade’s stages and its vital role in bridging innate and adaptive immunity.

All pathways lead to the formation of C3 convertases (C3bBb or C4b2b), which further cleave the central protein of the cascade, complement C3, into the small anaphylatoxin C3a and the larger...

Feb 14, 2023 · Several complement components are discovered and numbered according to the order of discovery. Various aspects and functions of the complement system and its role in the …

Jul 7, 2025 · This diagram depicts Complement Cascade and Function and explains the details of Complement Cascade and Function.

The functions of complement include the attraction of inflammatory cells, opsinization to promote phagocytosis, immune complex clearance and direct microbial killing through the formation of …

The complement system has three pathways: classical, alternative, and lectin pathways. The classical pathway is activated by antibodies, and the alternative and lectin pathways are …

The complement cascade refers to a series of enzymatic reactions and binding protein interactions within the human immune system that initiate an inflammatory response to …