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  1. GD2 - Wikipedia

    GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally …

  2. 一文读懂——神经母细胞瘤的GD2免疫治疗 - 知乎

    Oct 24, 2023 · 本文将主要围绕已获批上市的GD2单抗展开,对初治高危及复发/难治性神经母细胞瘤的治疗方案,各种GD2单抗在结构、疗效及安全性方面的证据进行深入分析,并针对GD2单 …

  3. Ganglioside GD2 (Disialoganglioside GD2) | 肿瘤相关抗原 | MCE

    Ganglioside GD2 (Disialoganglioside GD2) 属于神经节苷脂家族成员,是一种肿瘤相关抗原 (tumor-associated antigen),几乎在所有神经母细胞瘤 (neuroblastoma) 以及大多数黑色素瘤 …

  4. Nature Medicine丨第一代靶向GD2 CAR-T治疗神经母细胞瘤患者 …

    Feb 18, 2025 · 在本临床研究中,尽管使用由于缺乏共刺激域而不再使用的第一代载体,但复发/难治性神经母细胞瘤患者在接受GD2 CAR-T细胞疗法后实现了长期疾病控制,其中1名患者目前 …

  5. Biology of GD2 ganglioside: implications for cancer immunotherapy

    While GD2-blocking antibodies have the advantage of precisely identifying GD2, their different modes of actions such as antigen blocking, masking, clustering or internalization hinder …

  6. GD2: hopes and challenges for the treatment of pediatric ... - Nature

    Aug 21, 2025 · This work provides an overview of GD2 biology in terms of synthesis pathway and expression, as well as a critical review of the GD2-based targeted therapies for pediatric CNS …

  7. GD2单克隆抗体_百度百科

    GD2单克隆抗体是一种靶向神经母细胞瘤细胞表面过度表达GD2分子的免疫治疗药物,通过与GD2结合触发抗体依赖性细胞毒性(ADCC)和补体依赖的细胞毒性(CDC),诱导肿瘤细胞 …

  8. “凯”卷有益丨聚焦ANR 2025:神经母细胞瘤GD2单抗免疫治疗最新 …

    Jun 26, 2025 · GD2作为存在于NB细胞膜表面呈特异性高表达的抗原,成为NB免疫治疗的理想靶点。 近年来,随着创新药物的不断发展,靶向GD2的抗体药物为改善NB患者的治疗结局带来 …

  9. GD2 is a Crucial Ganglioside in the Signal Modulation and …

    Feb 7, 2025 · On the other hand, GD2 is expressed in more restricted cells than GD3, enabling anti-GD2 immune therapy to be more applicable for immunotherapy. Recently, the expression …

  10. CCR:GD2 CAR-T治疗髓母细胞瘤最新进展-MedSci.cn

    Jul 29, 2024 · 展示了针对二唾液酸神经节苷脂(GD2)的嵌合抗原受体 (CAR T) 细胞疗法的研究,旨在发现一种潜在更有效并减少长期治疗副作用的治疗方法。