5 days ago · Cancer cells that hijacked mitochondria disguised themselves with PD-L1, an immune checkpoint. Cancer cells also used the MHC-I (major histocompatibility complex class I) protein.

May 10, 2024 · Authors note that tumors likely employ a variety of strategies to evade immune detection. But the discovery could lead to a new approach for targeted cancer therapies.

The present study was initiated by comparing publicly available transcription profiles of tumor tissues from responsive and resistant ICB-treated patients across various cancer types.

6 days ago · Immune checkpoint molecules play a central role in regulating T cell function, maintaining immune homeostasis, and facilitating tumor immune evasion, making them critical targets in cancer …

2 days ago · Stanford University-led researchers report that tumor cells hijack mitochondria from immune cells, reducing anti-tumor immune function and activating cGAS-STING and type I interferon …

Nov 1, 2022 · Cancer is the second leading cause of death worldwide. Traditional approaches, such as surgery, chemotherapy, and radiotherapy have been the main canc…

Nov 13, 2025 · Tumor-associated immune checkpoints (ICPs) and their effects on mediating T cell activation. This figure illustrates the complex interplay between tumor-associated ICPs and T cell …

Mar 13, 2025 · However, tumor cells have developed sophisticated ways to evade detection, including hijacking the immune system’s brake mechanism, known as immune checkpoints.

Identified as a hallmark in 2011, ten years after the seminal “The Hallmarks of Cancer” paper was published in Cell, the concept reflects the critical role the immune system plays in both suppressing …

Discover how cancer cells bypass immune defenses and explore innovative strategies to combat the disease through scientific insights and therapeutic approaches.