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Why should you think twice before giving ONDANSETRON with TRAMADOL? 💊⚠️ This is an important drug interaction every medical student, doctor, nurse and healthcare professional should know. 🔴 TRAMADOL is a serotonergic opioid. It increases serotonin activity in addition to its opioid effects. 🟡 ONDANSETRON is a 5-HT3 receptor antagonist. Although the exact clinical significance of its serotonergic interaction remains debated, official prescribing information warns about serotonin syndrome when
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